1. Toxicity and Underlying Mechanism Identification using Zebra fish Model | Developmental toxicity in developing embryo |
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Neurotoxicity (Behavior Assay) in embryos and adults | |
Endocrine disruption | |
Mitochondrial toxicity | |
Aquatic toxicity | |
Role of miRNA and DNA methylation | |
Target: POPs, OCPs, EDCs, Nanoparticles, Microplastics etc |
2. Harmonized Experimental | Effect of low concentration and chemical mixture on non-linear response |
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Comprehensive mechanism underlying metabolic disorders | |
(Obesity, Type 2-Diabetes, Dementia) |
3. Environmental Toxico-Informatics | (Single-cell) RNA-seq analysis |
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Environmental Toxico-Metabolomics | |
Integrated Omics analysis | |
Functional Toxico-genomics |
4. Alternative toxicity testing and Regulatory Toxicology | Toxicity prediction using QSAR models |
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Nano-QSAR model development | |
Preparation and validation of Chemical Safety Report (CSR) |
5. Risk Assessment | Cumulative risk assessment |
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Multi-route, multi-media human health risk assessment |